γ－aminobutyric acid (Gamma-aminobutyric acid, GABA) is a non-protein amino acid, which is widely found in vertebrates, plants and microorganisms.
There are currently three production methods for GABA: chemical synthesis, plant enrichment, and biotransformation.
The reaction conditions of chemical synthesis are relatively severe, and there are chemical residues. Even if the purity is high, it is not a natural product, and is mainly used in the chemical and pharmaceutical fields.
The plant enrichment method uses the endogenous enzyme transformation of plant tissues to prepare GABA, but the GABA obtained by this method has low purity and is mostly used in the food industry. There are many GABA ingredients made from rice germ or germinated brown rice on the market to produce functional foods with functions of relieving fatigue, assisting in lowering blood pressure, and improving sleep.
The early research of the biotransformation method used Escherichia coli as the production strain. During the fermentation and culture process, the decarboxylation of glutamate decarboxylase was used to convert L-glutamic acid into GABA, and the pure GABA product was obtained after separation and purification. With the continuous development of biotechnology, some strains that also contain glutamate decarboxylase, such as yeast and lactic acid bacteria, have gradually replaced E. coli, thereby obtaining safer products.
Our GABA is fermented with our own research and development enzyme, and the purity is able to over 99%.
Insomnia is the most common type of sleep disorders. About 100 million people in China experience insomnia and 300 million people have sleep problems.
What are the symptoms of sleep disorders?
1. Decreased sleep: difficulty falling asleep, light sleep, etc.
2. Increased sleep: sleepiness, etc.
3. Unusual sleep behaviors: sleepwalking, nightmare, etc.
4. Irregular sleep-wake rhythm
What causes sleep disorders?
Sleep problems can be triggered by various factors, including:
1. Biological (such as genetics and body temperature changes)
2. Social and psychological (such as inner conflicts and cognitive errors)
3. Environmental (such as stress from life and sleep environment)
4. Psychiatric (such as anxiety disorders and depression)
1. The gut-brain axis (GBA)
2. The blood-brain barrier (BBB)
3. Through metabolic pathways in the body
